An In Silico and an In Vitro Inhibition Analysis of Glycogen Phosphorylase by Flavonoids, Styrylchromones, and Pyrazoles

An In Silico and an In Vitro Inhibition Analysis of Glycogen Phosphorylase by Flavonoids, Styrylchromones, and Pyrazoles

Glycogen phosphorylase (GP) is a key enzyme in the glycogenolysis pathway. GP inhibitors are currently under investigation as a new liver-targeted approach to managing type 2 diabetes <i>mellitus</i> (DM). The aim of the present study was to evaluate the inhibitory activity of a panel of...

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Bibliographic Details
Main Authors: Sónia Rocha, Natália Aniceto, Rita C. Guedes, Hélio M. T. Albuquerque, Vera L. M. Silva, Artur M. S. Silva, Maria Luísa Corvo, Eduarda Fernandes, Marisa Freitas
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Nutrients
Subjects:
natural compounds
synthetic compounds
glycogen phosphorylase
structure–activity relationship
type 2 diabetes
Online Access:https://www.mdpi.com/2072-6643/14/2/306

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https://www.mdpi.com/2072-6643/14/2/306

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