Deficient DNASE1L3 facilitates neutrophil extracellular traps‐induced invasion via cyclic GMP‐AMP synthase and the non‐canonical NF‐κB pathway in diabetic hepatocellular carcinoma

Deficient DNASE1L3 facilitates neutrophil extracellular traps‐induced invasion via cyclic GMP‐AMP synthase and the non‐canonical NF‐κB pathway in diabetic hepatocellular carcinoma

Abstract Objective Diabetic hepatocellular carcinoma (HCC) patients have high mortality and metastasis rates. Diabetic conditions promote neutrophil extracellular traps (NETs) generation, which mediates HCC metastasis and invasion. However, whether and how diabetes‐induced NETs trigger HCC invasion...

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Bibliographic Details
Main Authors: Na Li, Xue Zheng, Mianrong Chen, Li Huang, Li Chen, Rui Huo, Xiaotong Li, Yucan Huang, Mingwen Sun, Suiqing Mai, Zhuoyi Wu, Hui Zhang, Jinbao Liu, Chun‐tao Yang
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Clinical & Translational Immunology
Subjects:
cyclic GMP‐AMP synthase
diabetes
hepatocellular carcinoma
metastasis
neutrophil extracellular traps
non‐canonical NF‐κB pathway
Online Access:https://doi.org/10.1002/cti2.1386

Internet

https://doi.org/10.1002/cti2.1386

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