Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT

Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT

BackgroundEpithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated with the suppressing renal connective tissue growth factor exp...

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Bibliographic Details
Main Authors: Sundong Lin, Lechu Yu, Yongqing Ni, Lulu He, Xiaolu Weng, Xuemian Lu, Chi Zhang
Format: Article
Language:English
Published: Korean Diabetes Association 2020-02-01
Series:Diabetes & Metabolism Journal
Subjects:
epithelial-mesenchymal transition
fibroblast growth factor 21
fibrosis
kidney
transforming growth factor beta
tumor suppressor protein p53
Online Access:http://e-dmj.org/upload/pdf/dmj-44-158.pdf

Internet

http://e-dmj.org/upload/pdf/dmj-44-158.pdf

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