Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells

Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells

Summary: Mutations in the gene encoding DNA methyltransferase 3A (DNMT3A) are the most common cause of clonal hematopoiesis and are among the most common initiating events of acute myeloid leukemia (AML). Studies in germline and somatic Dnmt3a knockout mice have identified focal, canonical hypomethy...

Full description

Bibliographic Details
Main Authors: Amanda M. Smith, Angela M. Verdoni, Haley J. Abel, David Y. Chen, Shamika Ketkar, Elizabeth R. Leight, Christopher A. Miller, Timothy J. Ley
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222002747

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222002747

Similar Items