Characterization of large volume subcutaneous injections using computed tomography imaging and simultaneous pressure measurements

Characterization of large volume subcutaneous injections using computed tomography imaging and simultaneous pressure measurements

Many commercially available biologics, previously delivered only intravenously, are being re-formulated for subcutaneous delivery to improve patient access and compliance. However, due to inherent solubility limitations, large volume injections (more than 2 mL) are typically required. Different stra...

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Bibliographic Details
Main Authors: Mona Purcell, Sahab Babaee, Michael Galluppi, John Cline, Guangli Hu, Ioan Petrescu, Jennifer Hughes, Meredith Allen, Eric Messina, Steven Persak, Yogita Krishnamachari, Ashley Lay-Fortenbery, Corin O. Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Drug Delivery
Subjects:
Subcutaneous
hyaluronidase
computed tomography
minipig
in vivo
Online Access:https://www.frontiersin.org/articles/10.3389/fddev.2023.1223177/full

Internet

https://www.frontiersin.org/articles/10.3389/fddev.2023.1223177/full

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