Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity

Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity

Abstract Background The close interaction and interdependence of astrocytes and neurons allows for the possibility that astrocyte dysfunction contributes to and amplifies neurodegenerative pathology. Molecular pathways that trigger reactive astrocytes may represent important targets to preserve norm...

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Bibliographic Details
Main Authors: Elizabeth E. Evans, Vikas Mishra, Crystal Mallow, Elaine M. Gersz, Leslie Balch, Alan Howell, Christine Reilly, Ernest S. Smith, Terrence L. Fisher, Maurice Zauderer
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Neuroinflammation
Subjects:
Semaphorin
Neurodegeneration
Reactive astrocytes
Huntington’s disease
Alzheimer’s disease
Metabolic reprogramming
Online Access:https://doi.org/10.1186/s12974-022-02509-8

Internet

https://doi.org/10.1186/s12974-022-02509-8

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