Evaluating the Effect of Interleukin-4 in the 3xTg Mouse Model of Alzheimer’s Disease

Chronic neuroinflammation has long been hypothesized to be involved in Alzheimer’s Disease (AD) progression. Previous research suggests that both anti-inflammatory and inflammatory microglia ameliorate amyloid pathology, but the latter worsen tau pathology. In this study, we sought to determine whet...

Full description

Bibliographic Details
Main Authors: Dawling A. Dionisio-Santos, Adib Behrouzi, John A. Olschowka, M. Kerry O’Banion
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00441/full