Stability Indicating HPLC-ECD Method for the Analysis of Clarithromycin in Pharmaceutical Dosage Forms: Method Scaling versus Re-Validation

Stability Indicating HPLC-ECD Method for the Analysis of Clarithromycin in Pharmaceutical Dosage Forms: Method Scaling versus Re-Validation

An isocratic high-performance liquid chromatographic method using electrochemical detection (HPLC-ECD) for the quantitation of clarithromycin (CLA) was developed using Response Surface Methodology (RSM) based on a Central Composite Design (CCD). The method was validated using International Conferenc...

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Bibliographic Details
Main Authors: Pedzisai A. Makoni, Mellisa T.R. Chikukwa, Sandile M.M. Khamanga, Roderick B. Walker
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Scientia Pharmaceutica
Subjects:
clarithromycin
electrochemical detection
central composite design
method validation
usp method scaling
stability-indicating
Online Access:https://www.mdpi.com/2218-0532/87/4/31

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https://www.mdpi.com/2218-0532/87/4/31

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