Differential Cellular and Molecular Effects of Butyrate and Trichostatin A on Vascular Smooth Muscle Cells

Differential Cellular and Molecular Effects of Butyrate and Trichostatin A on Vascular Smooth Muscle Cells

The histone deacetylase (HDAC) inhibitors, butyrate and trichostatin A (TSA), are epigenetic histone modifiers and proliferation inhibitors by downregulating cyclin D1, a positive cell cycle regulator, and upregulating p21Cip1 and INK family of proteins, negative cell cycle regulators. Our recent st...

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Bibliographic Details
Main Authors: Kasturi Ranganna, Frank M. Yatsu, Omana P. Mathew, Shirlette G. Milton
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:Pharmaceuticals
Subjects:
butyrate
trichostatin A
vascular smooth muscle cells
proliferation
cyclin D1
HDAC
Online Access:http://www.mdpi.com/1424-8247/5/9/925

Internet

http://www.mdpi.com/1424-8247/5/9/925

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