β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

Expansion of biliary epithelial cells (BECs) during ductular reaction (DR) is observed in liver diseases including cystic fibrosis (CF), and associated with inflammation and fibrosis, albeit without complete understanding of underlying mechanism. Using two different genetic mouse knockouts of β-cate...

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Bibliographic Details
Main Authors: Shikai Hu, Jacquelyn O Russell, Silvia Liu, Catherine Cao, Jackson McGaughey, Ravi Rai, Karis Kosar, Junyan Tao, Edward Hurley, Minakshi Poddar, Sucha Singh, Aaron Bell, Donghun Shin, Reben Raeman, Aatur D Singhi, Kari Nejak-Bowen, Sungjin Ko, Satdarshan P Monga
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
ductular reaction
beta-catenin
NF-κB
cystic fibrosis
cholangiocytes
liver fibrosis
Online Access:https://elifesciences.org/articles/71310

Internet

https://elifesciences.org/articles/71310

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