ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca<sup>2+</sup> Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ

ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca<sup>2+</sup> Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ

ATPase inhibitory factor-1 (IF1) preserves cellular ATP under conditions of respiratory collapse, yet the function of IF1 under normal respiring conditions is unresolved. We tested the hypothesis that IF1 promotes mitochondrial dysfunction and pathological cardiomyocyte hypertrophy in the context of...

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Bibliographic Details
Main Authors: Mario G. Pavez-Giani, Pablo I. Sánchez-Aguilera, Nils Bomer, Shigeki Miyamoto, Harmen G. Booij, Paula Giraldo, Silke U. Oberdorf-Maass, Kirsten T. Nijholt, Salva R. Yurista, Hendrik Milting, Peter van der Meer, Rudolf A. de Boer, Joan Heller Brown, Herman W. H. Sillje, B. Daan Westenbrink
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
calcium handling
heart failure
CaMKII
cardiomyocyte hypertrophy
Online Access:https://www.mdpi.com/1422-0067/22/9/4427

Internet

https://www.mdpi.com/1422-0067/22/9/4427

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