MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma

MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma

Abstract Colorectal cancer (CRC) is one of the most common and deadliest forms of cancer. Myeloid Cell Leukemia 1 (MCL1), a pro-survival member of the Bcl-2 protein family is associated with chemo-resistance in CRC. The ability of MCL1 to inhibit apoptosis by binding to the BH3 domains of pro-apopto...

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Main Authors: Dechen Fu, Luke Pfannenstiel, Abeba Demelash, Yee Peng Phoon, Cameron Mayell, Claudia Cabrera, Caini Liu, Junjie Zhao, Josephine Dermawan, Deepa Patil, Jennifer DeVecchio, Matthew Kalady, Andrew J. Souers, Darren C. Phillips, Xiaoxia Li, Brian Gastman
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04334-y

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https://doi.org/10.1038/s41419-021-04334-y

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