Ajugol's upregulation of TFEB-mediated autophagy alleviates endoplasmic reticulum stress in chondrocytes and retards osteoarthritis progression in a mouse model

Ajugol's upregulation of TFEB-mediated autophagy alleviates endoplasmic reticulum stress in chondrocytes and retards osteoarthritis progression in a mouse model

Abstract Background Osteoarthritis (OA), a degenerative disease with a high global prevalence, is characterized by the degradation of the extracellular matrix (ECM) and the apoptosis of chondrocytes. Ajugol, a extract derived from the herb Rehmannia glutinosa, has not yet been investigated for its p...

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Bibliographic Details
Main Authors: Jingtao Wu, Heng Yu, Yangcan Jin, Jingquan Wang, Liwen Zhou, Teng Cheng, Zhao Zhang, Binghao Lin, Jiansen Miao, Zhongke Lin
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Chinese Medicine
Subjects:
Osteoarthritis
Ajugol
TBHP
TFEB
Autophagy
ER stress
Online Access:https://doi.org/10.1186/s13020-023-00824-7

Internet

https://doi.org/10.1186/s13020-023-00824-7

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