Case Report: Embedding “Digital Chronotherapy” Into Medical Devices—A Canine Validation for Controlling Status Epilepticus Through Multi-Scale Rhythmic Brain Stimulation

Case Report: Embedding “Digital Chronotherapy” Into Medical Devices—A Canine Validation for Controlling Status Epilepticus Through Multi-Scale Rhythmic Brain Stimulation

Circadian and other physiological rhythms play a key role in both normal homeostasis and disease processes. Such is the case of circadian and infradian seizure patterns observed in epilepsy. However, these rhythms are not fully exploited in the design of active implantable medical devices. In this p...

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Bibliographic Details
Main Authors: Mayela Zamora, Sebastian Meller, Filip Kajin, James J. Sermon, Robert Toth, Moaad Benjaber, Derk-Jan Dijk, Rafal Bogacz, Gregory A. Worrell, Antonio Valentin, Benoit Duchet, Holger A. Volk, Timothy Denison
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neuroscience
Subjects:
deep brain stimulation
centromedian thalamus
circadian
entrainment
epilepsy
chronotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.734265/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.734265/full

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