Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells

Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells

Group A streptococcus (GAS) is a versatile pathogen that causes a wide spectrum of diseases in humans. Invading host cells is a known strategy for GAS to avoid antibiotic killing and immune recognition. However, the underlying mechanisms of GAS resistance to intracellular killing need to be explored...

Full description

Bibliographic Details
Main Authors: Cheng-Lu Hsieh, Shu-Ying Hsieh, Hsuan-Min Huang, Shiou-Ling Lu, Hiroko Omori, Po-Xing Zheng, Yen-Ning Ho, Yi-Lin Cheng, Yee-Shin Lin, Chuan Chiang-Ni, Pei-Jane Tsai, Shu-Ying Wang, Ching-Chuan Liu, Takeshi Noda, Jiunn-Jong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Microbiology
Subjects:
Group A streptococcus (GAS)
nicotinamide (NAM)
NAD+ homeostasis
intracellular survival
endothelial cells (ECs)
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00117/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00117/full

Similar Items