Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical features that are largely indistinguishab...

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Bibliographic Details
Main Authors: David Ramonet, João Paulo L Daher, Brian M Lin, Klodjan Stafa, Jaekwang Kim, Rebecca Banerjee, Marie Westerlund, Olga Pletnikova, Liliane Glauser, Lichuan Yang, Ying Liu, Deborah A Swing, M Flint Beal, Juan C Troncoso, J Michael McCaffery, Nancy A Jenkins, Neal G Copeland, Dagmar Galter, Bobby Thomas, Michael K Lee, Ted M Dawson, Valina L Dawson, Darren J Moore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3071839?pdf=render

Internet

http://europepmc.org/articles/PMC3071839?pdf=render

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