Spatial and Quantitative Analysis of Tumor-Associated Macrophages: Intratumoral CD163-/PD-L1+ TAMs as a Marker of Favorable Clinical Outcomes in Triple-Negative Breast Cancer

Spatial and Quantitative Analysis of Tumor-Associated Macrophages: Intratumoral CD163-/PD-L1+ TAMs as a Marker of Favorable Clinical Outcomes in Triple-Negative Breast Cancer

Tumor-associated macrophages (TAMs) and abnormalities in cancer cells affect cancer progression and response to therapy. TAMs are a major component of the tumor microenvironment (TME) in breast cancer, with their invasion affecting clinical outcomes. Programmed death-ligand 1 (PD-L1), a target of im...

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Bibliographic Details
Main Authors: Hajime Shinohara, Maki Kobayashi, Kumiko Hayashi, Daichi Nogawa, Ayaka Asakawa, Yae Ohata, Kazuishi Kubota, Hisashi Takahashi, Miyuki Yamada, Masanori Tokunaga, Yusuke Kinugasa, Goshi Oda, Tsuyoshi Nakagawa, Iichiroh Onishi, Yuko Kinowaki, Morito Kurata, Kenichi Ohashi, Masanobu Kitagawa, Kouhei Yamamoto
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
tumor microenvironment
tumor-associated macrophage
multiplex immunohistochemistry
CD68
CD163
Online Access:https://www.mdpi.com/1422-0067/23/21/13235

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https://www.mdpi.com/1422-0067/23/21/13235

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