CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer

CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer

Abstract Background Both aberrant alternative splicing and m6A methylation play complicated roles in the development of pancreatic cancer (PC), while the relationship between these two RNA modifications remains unclear. Methods RNA sequencing (RNA-seq) was performed using 15 pairs of pancreatic duct...

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Bibliographic Details
Main Authors: Shi Chen, Can Yang, Zu-Wei Wang, Jian-Fei Hu, Jing-Jing Pan, Cheng-Yu Liao, Jia-Qiang Zhang, Jiang-Zhi Chen, Yi Huang, Long Huang, Qian Zhan, Yi-Feng Tian, Bai-Yong Shen, Yao-Dong Wang
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Hematology & Oncology
Subjects:
Pancreatic cancer
Alternative splicing
CLK1
SRSF5
M6A Modification
METTL14
Online Access:https://doi.org/10.1186/s13045-021-01072-8

Internet

https://doi.org/10.1186/s13045-021-01072-8

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