Patient-derived monoclonal antibodies to SARS-CoV-2 nucleocapsid protein N-terminal and C-terminal domains cross-react with their counterparts of SARS-CoV, but not other human betacoronaviruses

Patient-derived monoclonal antibodies to SARS-CoV-2 nucleocapsid protein N-terminal and C-terminal domains cross-react with their counterparts of SARS-CoV, but not other human betacoronaviruses

IntroductionSARS-CoV-2 nucleocapsid (N) protein plays a key role in multiple stages of the viral life cycle such as viral replication and assembly. This protein is more conserved than the Spike protein of the virus and can induce both humoral and cell-mediated immune responses, thereby becoming a ta...

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Bibliographic Details
Main Authors: Yingfen Wen, Wenjing Guo, Yuyi Min, Kexin Zhong, Xulei Zhang, Xiaomin Xing, Yuwei Tong, Yuejun Pan, Wenxin Hong, Weiping Cai, Lei Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
coronavirus
COVID-19
nucleocapsid protein
N-terminal
C-terminal
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1093709/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1093709/full

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