Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2

Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2

Abstract Originally discovered in the circulation of pregnant women as a protein secreted by placental trophoblasts, the metalloprotease pregnancy-associated plasma protein A (PAPP-A) is also widely expressed by many other tissues. It cleaves insulin-like growth factor-binding proteins (IGFBPs) to i...

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Bibliographic Details
Main Authors: Qihang Zhong, Honglei Chu, Guopeng Wang, Cheng Zhang, Rong Li, Fusheng Guo, Xinlu Meng, Xiaoguang Lei, Youli Zhou, Ruobing Ren, Lin Tao, Ningning Li, Ning Gao, Yuan Wei, Jie Qiao, Jing Hang
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00502-2

Internet

https://doi.org/10.1038/s41421-022-00502-2

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