Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment

Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment

Abstract Background Cutaneous melanoma exhibits heterogeneous metastatic patterns and prognosis. In this regard, liver metastasis, which is detected in ~ 10–20% of stage 4 patients, came to the fore of melanoma research, as it recently evolved as decisive indicator of treatment resistance to immune...

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Bibliographic Details
Main Authors: Sebastian A. Wohlfeil, Verena Häfele, Bianca Dietsch, Céline Weller, Carsten Sticht, Anna Sophia Jauch, Manuel Winkler, Christian David Schmid, Anna Lena Irkens, Ana Olsavszky, Kai Schledzewski, Philipp-Sebastian Reiners-Koch, Sergij Goerdt, Cyrill Géraud
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Translational Medicine
Subjects:
Cutaneous melanoma
Melanoma metastasis
Liver metastasis
Tumor heterogeneity
Anti-angiogenesis
Sorafenib
Online Access:https://doi.org/10.1186/s12967-022-03255-4

Internet

https://doi.org/10.1186/s12967-022-03255-4

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