Galangin ameliorates PTU-induced vitiligo in zebrafish and B16F10 cells by increasing melanogenesis through activation of the p38/JNK MAPK pathway

Galangin ameliorates PTU-induced vitiligo in zebrafish and B16F10 cells by increasing melanogenesis through activation of the p38/JNK MAPK pathway

ObjectiveAlpinia officinarum Hance is a traditional herb in Xinjiang for the treatment of vitiligo, and galangin (GA) is a flavonoid isolated from its roots. However, its therapeutic mechanism remains unclear.MethodsIn this study, 1-phenyl-2-thiourea (PTU) was used to establish a vitiligo model in z...

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Bibliographic Details
Main Authors: Zulipikaer Wusiman, Ai-Mei Zhang, Shu-Shu Zhang, Ping-Ping Zhao, Yu-Tong Kang, Yun Zhang, Zhi-Jian Li, Shi-Xia Huo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
galangin
zebrafish
B16F10 cells
tyrosinase
MAPK signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1521097/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2025.1521097/full

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