A Phase I Trial of Sirolimus with “7&3” Induction Chemotherapy in Patients with Newly Diagnosed Acute Myeloid Leukemia

A Phase I Trial of Sirolimus with “7&3” Induction Chemotherapy in Patients with Newly Diagnosed Acute Myeloid Leukemia

Chemotherapy remains a primary treatment for younger AML patients, though many relapse. Data from our group have shown that highly phosphorylated S6 in blasts may predict response to sirolimus given with chemotherapy. We report the results of a phase I study of this combination in newly diagnosed AM...

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Bibliographic Details
Main Authors: Neil Palmisiano, Grace Jeschke, Lindsay Wilde, Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O’Hara, Dolores Grosso, Thomas Klumpp, Ubaldo Martinez, John Wagner, Martin P. Carroll, Alexander Perl, Margaret Kasner
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
acute myeloid leukemia
mTORC
clinical trial
Online Access:https://www.mdpi.com/2072-6694/15/21/5129

Internet

https://www.mdpi.com/2072-6694/15/21/5129

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