FYCO1 Increase and Effect of Arimoclomol–Treatment in Human <i>VCP</i>–Pathology

FYCO1 Increase and Effect of Arimoclomol–Treatment in Human <i>VCP</i>–Pathology

Dominant <i>VCP</i>–mutations cause a variety of neurological manifestations including inclusion body myopathy with early–onset Paget disease and frontotemporal dementia 1 (IBMPFD). <i>VCP</i> encodes a ubiquitously expressed multifunctional protein that is a member of the AA...

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Bibliographic Details
Main Authors: Anne-Katrin Guettsches, Nancy Meyer, René P. Zahedi, Teresinha Evangelista, Thomas Muentefering, Tobias Ruck, Emmanuelle Lacene, Christoph Heute, Humberto Gonczarowska-Jorge, Benedikt Schoser, Sabine Krause, Andreas Hentschel, Matthias Vorgerd, Andreas Roos
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biomedicines
Subjects:
valosin–containing protein (VCP)
inclusion body myopathy with frontotemporal dementia and Paget’s disease of the bone (IBMPFD)
fibroblast proteomics
arimoclomol
autophagy
FYCO1
Online Access:https://www.mdpi.com/2227-9059/10/10/2443

Internet

https://www.mdpi.com/2227-9059/10/10/2443

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