Proteomic characterisation of perhexiline treatment on THP-1 M1 macrophage differentiation

Proteomic characterisation of perhexiline treatment on THP-1 M1 macrophage differentiation

BackgroundDysregulated inflammation is important in the pathogenesis of many diseases including cancer, allergy, and autoimmunity. Macrophage activation and polarisation are commonly involved in the initiation, maintenance and resolution of inflammation. Perhexiline (PHX), an antianginal drug, has b...

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Main Authors: Bimala Dhakal, Celine Man Ying Li, Mahnaz Ramezanpour, Ghais Houtak, Runhao Li, George Bouras, Alex Collela, Nusha Chegeni, Tim Kennion Chataway, Paul Drew, Benedetta C. Sallustio, Sarah Vreugde, Eric Smith, Guy Maddern, Giovanni Licari, Kevin Fenix
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
M1 macrolphage
perhexiline
quantitative proteomics
THP-1 derived macrophages
macrophage polarisation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1054588/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1054588/full

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