Identification of novel candidate targets for suppressing ovarian cancer progression through IL-33/ST2 axis components using the system biology approach

Identification of novel candidate targets for suppressing ovarian cancer progression through IL-33/ST2 axis components using the system biology approach

Background: Cancer-associated fibroblasts (CAFs) of ovarian cancer (OvC) are the most prevalent element of the tumor microenvironment (TM). By promoting angiogenesis, immunological suppression, and invasion, CAFs speed up the growth of tumors by changing the extracellular matrix’s structure and comp...

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Main Authors: Geovanny Genaro Reivan Ortiz, Carmen Iulia Ciongradi, M. V. N. L. Chaitanya, Jayasankar Narayanan, Mohamed Mohany, Salim S. Al-Rejaie, José Luis Arias-Gonzáles, Ioan Sârbu, Marjan Assefi, Shaik Vaseem Akram, Yusuf Döğüş, Abolfazl Bahrami, Reza Akhavan-Sigari
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
IL-33
ST2
ovarian cancer
cancer-associated fibroblasts
MAPKs-NF-κB
gene expression
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1189527/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1189527/full

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