The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts*

The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts*

The Niemann-Pick C1 (NPC1) protein regulates the transport of cholesterol from late endosomes/lysosomes to other compartments responsible for maintaining intracellular cholesterol homeostasis. The present study examined the expression of the NPC1 gene and the distribution of the NPC1 protein that re...

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Bibliographic Details
Main Authors: William S. Garver, David Jelinek, Gordon A. Francis, Bruce D. Murphy
Format: Article
Language:English
Published: Elsevier 2008-05-01
Series:Journal of Lipid Research
Subjects:
cholesterol homeostasis
coated-pit pathway
late endosomes/lysosomes
low density lipoprotein-derived cholesterol
sterol-regulatory element binding protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520425969

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http://www.sciencedirect.com/science/article/pii/S0022227520425969

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