Transcriptional programming of immunoregulatory responses in human Langerhans cells

Transcriptional programming of immunoregulatory responses in human Langerhans cells

Human epidermal Langerhans cells (LCs) maintain immune homeostasis in the skin. To examine transcriptional programming of human primary LCs during homeostasis, we performed scRNA-seq analysis of LCs before and after migration from the epidermis, coupled with functional assessment of their regulatory...

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Bibliographic Details
Main Authors: James Davies, Sofia Sirvent, Andres F. Vallejo, Kalum Clayton, Gemma Douilhet, Patrick S. Keeler, Jonathan West, Michael Ardern-Jones, Ben D. MacArthur, Harinder Singh, Marta E. Polak
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
dendritic cell (DC)
Langerhans cell (LC)
gene regulatory network (GRN)
transcriptional regulation
immune regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.892254/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.892254/full

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