High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis

High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis

Abstract Background The aim of study was to observe the effect of increased lactate levels during high-intensity interval training (HIIT) on protein lactylation, identify the target protein, and investigate the regulatory effect of lactylation on the function of the protein. Methods C57B/L6 mice wer...

Full description

Bibliographic Details
Main Authors:	Xuefei Chen, Wenhua Huang, Jingbo Zhang, Yanjun Li, Zheng Xing, Lanlan Guo, Hongfeng Jiang, Jing Zhang
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Series:	BMC Biology
Subjects:	High-intensity interval training Lactylation Fatty acid synthase Fat loss
Online Access:	https://doi.org/10.1186/s12915-023-01698-9

Similar Items

High-Intensity Interval Training Induces Protein Lactylation in Different Tissues of Mice with Specificity and Time Dependence
by: Wenhua Huang, et al.
Published: (2023-05-01)

Histone Lactylation Participates in Psoriasis Progression by Regulating the Adiponectin Expression
by: Zhao S, et al.
Published: (2024-01-01)

Ubiquitous protein lactylation in health and diseases
by: Junyong Wang, et al.
Published: (2024-02-01)

Lactylation may be a Novel Posttranslational Modification in Inflammation in Neonatal Hypoxic-Ischemic Encephalopathy
by: Yue Zhou, et al.
Published: (2022-06-01)

The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment
by: Yan Zhang, et al.
Published: (2023-09-01)

Potential biomarker for diagnosis and therapy of sepsis: Lactylation
by: ZeXian Sun, et al.
Published: (2023-10-01)

Scientific Opinion on the re-evaluation of sodium stearoyl-2-lactylate (E 481) and calcium stearoyl-2-lactylate (E 482) as food additives
by: EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)
Published: (2013-05-01)

Post-translational protein lactylation modification in health and diseases: a double-edged sword
by: Hang Gong, et al.
Published: (2024-01-01)

Lactylation, an emerging hallmark of metabolic reprogramming: Current progress and open challenges
by: Xuelian Liu, et al.
Published: (2022-08-01)

Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration
by: Thibaut Desgeorges, et al.
Published: (2024-05-01)

The Role of Lactylation in Mental Illness: Emphasis on Microglia
by: Adonis Sfera, et al.
Published: (2023-05-01)

Effect of lactylation on functional and structural properties of gluten
by: Yu Wang, et al.
Published: (2022-10-01)

Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription
by: Yu Zhang, et al.
Published: (2024-03-01)

Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects
by: An-Na Chen, et al.
Published: (2021-06-01)

Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression
by: Lihua Chen, et al.
Published: (2022-10-01)

Lactylation-Related Gene Signature Effectively Predicts Prognosis and Treatment Responsiveness in Hepatocellular Carcinoma
by: Zhe Cheng, et al.
Published: (2023-04-01)

Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer
by: Jian Deng, et al.
Published: (2023-11-01)

Interplay between metabolic reprogramming and post-translational modifications: from glycolysis to lactylation
by: Hengwei Wu, et al.
Published: (2023-06-01)

Immunological profile of lactylation-related genes in Crohn’s disease: a comprehensive analysis based on bulk and single-cell RNA sequencing data
by: Jingtong Wu, et al.
Published: (2024-03-01)

Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
by: Hao Han, et al.
Published: (2023-11-01)

Research progress in the role and mechanism of lactylation in diseases
by: GE Lingling, et al.
Published: (2023-03-01)

Functions and mechanisms of lactylation in carcinogenesis and immunosuppression
by: Jing Su, et al.
Published: (2023-08-01)

Lactate promotes myogenesis via activating H3K9 lactylation‐dependent up‐regulation of Neu2 expression
by: Weilong Dai, et al.
Published: (2023-12-01)

Demethylzeylasteral targets lactate to suppress the tumorigenicity of liver cancer stem cells: It is attributed to histone lactylation?
by: Hang Gong, et al.
Published: (2023-08-01)

Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei
by: Naiwen Zhang, et al.
Published: (2021-10-01)

Identification of lactylation related model to predict prognostic, tumor infiltrating immunocytes and response of immunotherapy in gastric cancer
by: Hao Yang, et al.
Published: (2023-03-01)

Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation
by: Madison L. Mattingly, et al.
Published: (2023-09-01)

The role and mechanism of histone lactylation in health and diseases
by: Yumei Xie, et al.
Published: (2022-08-01)

Oxamate enhances the efficacy of CAR-T therapy against glioblastoma via suppressing ectonucleotidases and CCR8 lactylation
by: Ting Sun, et al.
Published: (2023-09-01)

Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells
by: Lianhong Pan, et al.
Published: (2022-07-01)

Effect of Lactylated Gluten and Freeze-Thaw Cycles on Frozen Dough: From Water State and Microstructure
by: Yan Li, et al.
Published: (2023-09-01)

Histone lactylation regulates cancer progression by reshaping the tumor microenvironment
by: Junxing Qu, et al.
Published: (2023-10-01)

The mechanism of PFK-1 in the occurrence and development of bladder cancer by regulating ZEB1 lactylation
by: Rong Wang, et al.
Published: (2024-03-01)

A pan-cancer multi-omics analysis of lactylation genes associated with tumor microenvironment and cancer development
by: Zhixuan Wu, et al.
Published: (2024-03-01)

Endothelial Cell‐Derived Lactate Triggers Bone Mesenchymal Stem Cell Histone Lactylation to Attenuate Osteoporosis
by: Jinhui Wu, et al.
Published: (2023-11-01)

Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii
by: Wei Zhao, et al.
Published: (2022-05-01)

Systematic Analysis of Lysine Lactylation in the Plant Fungal Pathogen Botrytis cinerea
by: Mingming Gao, et al.
Published: (2020-10-01)

Scopolamine regulates the osteogenic differentiation of human periodontal ligament stem cells through lactylation modification of RUNX2 protein
by: Ying Wu, et al.
Published: (2024-02-01)

Lactate-induced lactylation in skeletal muscle is associated with insulin resistance in humans
by: Dominic Maschari, et al.
Published: (2022-08-01)

Enterobacterial LPS-inducible LINC00152 is regulated by histone lactylation and promotes cancer cells invasion and migration
by: Jianwei Wang, et al.
Published: (2022-07-01)