Disruption of NBS1/MRN Complex Formation by E4orf3 Supports NF-κB That Licenses E1B55K-Deleted Adenovirus-Infected Cells to Accumulate DNA>4n

Disruption of NBS1/MRN Complex Formation by E4orf3 Supports NF-κB That Licenses E1B55K-Deleted Adenovirus-Infected Cells to Accumulate DNA>4n

ABSTRACT Cells increase their DNA content greater than the G2/M (DNA > 4n) phases along the path to cancer. The signals that support this increase in DNA content remain poorly understood. Cells infected with adenovirus (Ad) similarly develop DNA > 4n and share a need to bypass the DNA damage r...

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Bibliographic Details
Main Authors: Nujud Almuzaini, Madison Moore, Marjorie Robert-Guroff, Michael A. Thomas
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:Microbiology Spectrum
Subjects:
ATM
DNA damage
DNA>4n
E1B55K-deleted Ad
E4orf3
MRN
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01881-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.01881-21

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