Systematic prediction of degrons and E3 ubiquitin ligase binding via deep learning

Systematic prediction of degrons and E3 ubiquitin ligase binding via deep learning

Abstract Background Degrons are short linear motifs, bound by E3 ubiquitin ligase to target protein substrates to be degraded by the ubiquitin-proteasome system. Mutations leading to deregulation of degron functionality disrupt control of protein abundance due to mistargeting of proteins destined fo...

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Bibliographic Details
Main Authors: Chao Hou, Yuxuan Li, Mengyao Wang, Hong Wu, Tingting Li
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Biology
Subjects:
Degron
E3 Ubiquitin ligase
Protein degradation
Deep learning
Cancer driver mutation
Online Access:https://doi.org/10.1186/s12915-022-01364-6

Internet

https://doi.org/10.1186/s12915-022-01364-6

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