Candida albicans Targets a Lipid Raft/Dectin-1 Platform to Enter Human Monocytes and Induce Antigen Specific T Cell Responses.

Candida albicans Targets a Lipid Raft/Dectin-1 Platform to Enter Human Monocytes and Induce Antigen Specific T Cell Responses.

Several pathogens have been described to enter host cells via cholesterol-enriched membrane lipid raft microdomains. We found that disruption of lipid rafts by the cholesterol-extracting agent methyl-β-cyclodextrin or by the cholesterol-binding antifungal drug Amphotericin B strongly impairs the upt...

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Bibliographic Details
Main Authors: Valeria de Turris, Raffaela Teloni, Paola Chiani, Carla Bromuro, Sabrina Mariotti, Manuela Pardini, Roberto Nisini, Antonella Torosantucci, Maria Cristina Gagliardi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4643028?pdf=render

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http://europepmc.org/articles/PMC4643028?pdf=render

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