Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma

Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma

Hepatocellular carcinomas (HCCs) usually arise from chronic liver disease (CLD). Precancerous cells in chronically inflamed environments may be ‘epigenetically primed’, sensitising them to oncogenic transformation. We investigated whether epigenetic priming in CLD may affect HCC outcomes by influenc...

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Bibliographic Details
Main Authors: John Gallon, Mairene Coto‐Llerena, Caner Ercan, Gaia Bianco, Viola Paradiso, Sandro Nuciforo, Stephanie Taha‐Melitz, Marie‐Anne Meier, Tujana Boldanova, Sofía Pérez‐del‐Pulgar, Sergio Rodríguez‐Tajes, Markus vonFlüe, Savas D. Soysal, Otto Kollmar, Josep M. Llovet, Augusto Villanueva, Luigi M. Terracciano, Markus H. Heim, Charlotte K. Y. Ng, Salvatore Piscuoglio
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Molecular Oncology
Subjects:
chronic liver disease
epigenetic priming
hepatocellular carcinoma
methylation
Online Access:https://doi.org/10.1002/1878-0261.13154

Internet

https://doi.org/10.1002/1878-0261.13154

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