Early-phase administration of human amnion-derived stem cells ameliorates neurobehavioral deficits of intracerebral hemorrhage by suppressing local inflammation and apoptosis

Early-phase administration of human amnion-derived stem cells ameliorates neurobehavioral deficits of intracerebral hemorrhage by suppressing local inflammation and apoptosis

Abstract Background Intracerebral hemorrhage (ICH) is a significant cause of death and disabilities. Recently, cell therapies using mesenchymal stem cells have been shown to improve ICH-induced neurobehavioral deficits. Based on these findings, we designed this study to evaluate the therapeutic effi...

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Bibliographic Details
Main Authors: Yoji Kuramoto, Mitsugu Fujita, Toshinori Takagi, Yuki Takeda, Nobutaka Doe, Kenichi Yamahara, Shinichi Yoshimura
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Neuroinflammation
Subjects:
Human amnion-derived stem cell
Intracerebral hemorrhage
Macrophage
Microglia
Apoptosis
Inflammation
Online Access:https://doi.org/10.1186/s12974-022-02411-3

Internet

https://doi.org/10.1186/s12974-022-02411-3

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