SIMPL enhancement of tumor necrosis factor-α dependent p65-MED1 complex formation is required for mammalian hematopoietic stem and progenitor cell function.

SIMPL enhancement of tumor necrosis factor-α dependent p65-MED1 complex formation is required for mammalian hematopoietic stem and progenitor cell function.

Significant insight into the signaling pathways leading to activation of the Rel transcription factor family, collectively termed NF-κB, has been gained. Less well understood is how subsets of NF-κB-dependent genes are regulated in a signal specific manner. The SIMPL protein (signaling molecule that...

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Bibliographic Details
Main Authors: Weina Zhao, Erin Breese, Allison Bowers, Jonathan Hoggatt, Louis M Pelus, Hal E Broxmeyer, Mark Goebl, Maureen A Harrington
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3632537?pdf=render

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http://europepmc.org/articles/PMC3632537?pdf=render

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