Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes

Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes

Abstract Homologous recombination (HR) is an essential double-stranded DNA break repair pathway. In HR, Rad52 facilitates the formation of Rad51 nucleoprotein filaments on RPA-coated ssDNA. Here, we decipher how Rad52 functions using single-particle cryo-electron microscopy and biophysical approache...

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Bibliographic Details
Main Authors: Jaigeeth Deveryshetty, Rahul Chadda, Jenna R. Mattice, Simrithaa Karunakaran, Michael J. Rau, Katherine Basore, Nilisha Pokhrel, Noah Englander, James A. J. Fitzpatrick, Brian Bothner, Edwin Antony
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41993-1

Internet

https://doi.org/10.1038/s41467-023-41993-1

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