Excess of heme induces tissue factor-dependent activation of coagulation in mice

An excess of free heme is present in the blood during many types of hemolytic anemia. This has been linked to organ damage caused by heme-mediated oxidative stress and vascular inflammation. We investigated the mechanism of heme-induced coagulation activation in vivo. Heme caused coagulation activat...

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Main Authors: Erica M. Sparkenbaugh, Pichika Chantrathammachart, Shaobin Wang, Will Jonas, Daniel Kirchhofer, David Gailani, Andras Gruber, Raj Kasthuri, Nigel S. Key, Nigel Mackman, Rafal Pawlinski
格式: 文件
语言:English
出版: Ferrata Storti Foundation 2015-03-01
丛编:Haematologica
在线阅读:https://haematologica.org/article/view/7301