The shelf life of ASDs: 2. Predicting the shelf life at storage conditions

The shelf life of ASDs: 2. Predicting the shelf life at storage conditions

Amorphous solid dispersions (ASDs) are a widely used formulation technology for poorly water-soluble active pharmaceutical ingredients (API). Depending on the API-polymer combination and API load in the ASD, the amorphous API might be thermodynamically metastable and crystallize over time. The cryst...

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Bibliographic Details
Main Authors: Friederike Wolbert, Christian Luebbert, Gabriele Sadowski
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Amorphous solid dispersion
Physical stability
Water sorption
PC-SAFT
Crystallization kinetics
Long term stability
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156723000518

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http://www.sciencedirect.com/science/article/pii/S2590156723000518

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