AMG-510 and cisplatin combination increases antitumor effect in lung adenocarcinoma with mutation of KRAS G12C: a preclinical and translational research

AMG-510 and cisplatin combination increases antitumor effect in lung adenocarcinoma with mutation of KRAS G12C: a preclinical and translational research

Abstract Background The efficacy of monotherapy of AMG-510 is limited. This study explored whether the AMG-510 and cisplatin combination increases the anti-tumor effect in lung adenocarcinoma with the mutation of Kirsten rat sarcoma viral oncogene (KRAS) G12C. Methods Patients’ data were used to ana...

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Bibliographic Details
Main Authors: Lei-Lei Wu, Wen-Mei Jiang, Zhi-Yuan Liu, Yi-Yi Zhang, Jia-Yi Qian, Yu’e Liu, Yang-Yu Huang, Kun Li, Zhi-Xin Li, Guo-Wei Ma, Dong Xie
Format: Article
Language:English
Published: Springer 2023-06-01
Series:Discover Oncology
Subjects:
KRAS G12C mutation
AMG-510
Cisplatin
In vivo
Translational medicine
Online Access:https://doi.org/10.1007/s12672-023-00698-z

Internet

https://doi.org/10.1007/s12672-023-00698-z

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