Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several physiological and pathological states, including Alzheimer’s disease (AD). With a prominent extracellular chaperone function, additional roles have been discussed for clusterin, including lipid transport an...

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Bibliographic Details
Main Authors: Evangeline M. Foster, Adrià Dangla-Valls, Simon Lovestone, Elena M. Ribe, Noel J. Buckley
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Neuroscience
Subjects:
neurodegeneration
amyloid
cell death
neuroprotection
DKK1
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00164/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00164/full

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