A retrotransposon-derived DNA zip code internalizes myeloma cells through Clathrin-Rab5a-mediated endocytosis

A retrotransposon-derived DNA zip code internalizes myeloma cells through Clathrin-Rab5a-mediated endocytosis

IntroductionWe have demonstrated that transposons derived from ctDNA can be transferred between cancer cells. The present research aimed to investigate the cellular uptake and intracellular trafficking of Multiple Myeloma-zip code (MM-ZC), a cell-specific zip code, in myeloma cell lines. We demonstr...

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Bibliographic Details
Main Authors: Pavan Kumar Puvvula, Lourdes Martinez-Medina, Munevver Cinar, Lei Feng, Andrey Pisarev, Anthony Johnson, Leon Bernal-Mizrachi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Oncology
Subjects:
myeloma
endocytosis
gene therapy
cancer biology
non-viral vectors
cell-specific targeted delivery
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1288724/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2024.1288724/full

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