Stomatin-like Protein 2 Promotes Tumor Cell Survival by Activating the JAK2-STAT3-PIM1 Pathway, Suggesting a Novel Therapy in CRC

Stomatin-like Protein 2 Promotes Tumor Cell Survival by Activating the JAK2-STAT3-PIM1 Pathway, Suggesting a Novel Therapy in CRC

Despite intensive efforts, a considerable proportion of colorectal cancer (CRC) patients develop local recurrence and distant metastasis. Stomatin-like protein 2 (SLP-2), a member of the highly conserved stomatin superfamily, is upregulated across cancer types. However, the biological and functional...

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Bibliographic Details
Main Authors: Qiang Liu, Anqi Li, Lisha Wang, Wei He, Ling Zhao, Chao Wu, Shasha Lu, Xuanguang Ye, Huiyong Zhao, Xiaohan Shen, Xiuying Xiao, Zebing Liu
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
stomatin-like protein 2
JAK2
STAT3
PIM1
colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520300358

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http://www.sciencedirect.com/science/article/pii/S2372770520300358

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