Exosome-like nanovesicles derived from Momordica charantia ameliorate delayed t-PA thrombolysis-induced hemorrhagic transformation by inhibiting the ONOO−/HMGB1/MMP-9 pathway

Exosome-like nanovesicles derived from Momordica charantia ameliorate delayed t-PA thrombolysis-induced hemorrhagic transformation by inhibiting the ONOO−/HMGB1/MMP-9 pathway

Hemorrhagic transformation (HT) and restrictive therapeutic time window are significant limitations of delayed t-PA (tissue-type plasminogen activator) thrombolytic therapy in ischemic stroke patients. Plant Momordica charantia-derived exosome-like nanovesicles (MC-ELNs) can protect the blood–brain...

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Bibliographic Details
Main Authors: Wan Wang, Peipei Wang, Zhiyan Liang, Zilu Qin, Ruiqi Su, Qilong Yin, Bin Wang, Jie Chen, Yide Zhang, Xuewen Wei, Linyan Huang, Shenyang Zhang, Suhua Qi
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Journal of Functional Foods
Subjects:
Cerebral ischemia-reperfusion injury
Momordica charantia-derived exosome-like nanovesicles (MC-ELNs)
Tissue plasminogen activator (t-PA)
Hemorrhagic transformation (HT)
Blood-brain barrier (BBB)
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464624000884

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http://www.sciencedirect.com/science/article/pii/S1756464624000884

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