Preclinical immunogenicity assessment of a cell-based inactivated whole-virion H5N1 influenza vaccine

Preclinical immunogenicity assessment of a cell-based inactivated whole-virion H5N1 influenza vaccine

In influenza vaccine development, Madin–Darby canine kidney (MDCK) cells provide multiple advantages, including large-scale production and egg independence. Several cell-based influenza vaccines have been approved worldwide. We cultured H5N1 virus in a serum-free MDCK cell suspension. The harvested...

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Bibliographic Details
Main Authors: Zhang Zhegang, Jiang Zheng, Deng Tao, Zhang Jiayou, Liu Bo, Liu Jing, Qiu Ran, Zhang Qingmei, Li Xuedan, Nian Xuanxuan, Hong Yue, Li Fang, Peng Feixia, Zhao Wei, Xia Zhiwu, Huang Shihe, Liang Shuyan, Chen Jinhua, Li Changgui, Yang Xiaoming
Format: Article
Language:English
Published: De Gruyter 2022-09-01
Series:Open Life Sciences
Subjects:
mdck cells
humoral immune response
cellular immune response
h5n1
vaccine
Online Access:https://doi.org/10.1515/biol-2022-0478

Internet

https://doi.org/10.1515/biol-2022-0478

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