AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway

AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway

Abstract Background Glioblastoma (GBM) is the most common brain tumor with the worst prognosis. Temozolomide is the only first-line drug for GBM. Unfortunately, the resistance issue is a classic problem. Therefore, it is essential to develop new drugs to treat GBM. As an oncogene, Skp2 is involved i...

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Bibliographic Details
Main Authors: Yizhi Zhang, Wan Li, Yihui Yang, Sen Zhang, Hong Yang, Yue Hao, Xu Fang, Guanhua Du, Jianyou Shi, Lianqiu Wu, Jinhua Wang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cancer Cell International
Subjects:
Glioblastoma
AAA237
BNIP3
Autophagosome–lysosome fusion
Online Access:https://doi.org/10.1186/s12935-023-03191-3

Internet

https://doi.org/10.1186/s12935-023-03191-3

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