Targeting Longevity Gene <i>SLC13A5</i>: A Novel Approach to Prevent Age-Related Bone Fragility and Osteoporosis

Targeting Longevity Gene <i>SLC13A5</i>: A Novel Approach to Prevent Age-Related Bone Fragility and Osteoporosis

Reduced expression of the plasma membrane citrate transporter <i>SLC13A5</i>, also known as INDY, has been linked to increased longevity and mitigated age-related cardiovascular and metabolic diseases. Citrate, a vital component of the tricarboxylic acid cycle, constitutes 1–5% of bone w...

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Bibliographic Details
Main Authors: Grit Zahn, Hannes A. Baukmann, Jasmine Wu, Jens Jordan, Andreas L. Birkenfeld, Naomi Dirckx, Marco F. Schmidt
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Metabolites
Subjects:
mINDY
<i>SLC13A5</i>
citrate
citrate transporter
NaCT
osteoporosis
Online Access:https://www.mdpi.com/2218-1989/13/12/1186

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