Inhibiting PRMT5 induces DNA damage and increases anti-proliferative activity of Niraparib, a PARP inhibitor, in models of breast and ovarian cancer

Inhibiting PRMT5 induces DNA damage and increases anti-proliferative activity of Niraparib, a PARP inhibitor, in models of breast and ovarian cancer

Abstract Background Inhibitors of Poly (ADP-Ribose) Polymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising the DNA repair activity of cancer cells. Although these agents extend progression-free survival in many patients, responses can be short lived...

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Bibliographic Details
Main Authors: Shane O’Brien, Michael Butticello, Christine Thompson, Boris Wilson, Anastasia Wyce, Vivek Mahajan, Ryan Kruger, Helai Mohammad, Andy Fedoriw
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Cancer
Subjects:
Combinations
Breast
Ovarian
PARP
Protein methyltransferase 5
Online Access:https://doi.org/10.1186/s12885-023-11260-z

Internet

https://doi.org/10.1186/s12885-023-11260-z

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