Structure based innovative approach to analyze aptaprobe–GPC3 complexes in hepatocellular carcinoma

Structure based innovative approach to analyze aptaprobe–GPC3 complexes in hepatocellular carcinoma

Abstract Background Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, is a biomarker of hepatocellular carcinoma (HCC) progression. Aptamers specifically binding to target biomolecules have recently emerged as clinical disease diagnosis targets. Here, we describe 3D structure-based a...

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Bibliographic Details
Main Authors: Woo-Ri Shin, Dae-Young Park, Ji Hun Kim, Jin-Pyo Lee, Nguyen Quang Thai, In-Hwan Oh, Simranjeet Singh Sekhon, Wooil Choi, Sung Yeon Kim, Byung-Kwan Cho, Sun Chang Kim, Jiho Min, Ji-Young Ahn, Yang-Hoon Kim
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Nanobiotechnology
Subjects:
Glypican-3
Hepatocellular carcinoma
Cancer diagnosis
Aptaprobe
Structure-based molecular interaction
Aptablotting
Online Access:https://doi.org/10.1186/s12951-022-01391-z

Internet

https://doi.org/10.1186/s12951-022-01391-z

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