Pathological mechanisms of connexin26-related hearing loss: Potassium recycling, ATP-calcium signaling, or energy supply?

Pathological mechanisms of connexin26-related hearing loss: Potassium recycling, ATP-calcium signaling, or energy supply?

Hereditary deafness is one of the most common human birth defects. GJB2 gene mutation is the most genetic etiology. Gap junction protein 26 (connexin26, Cx26) encoded by the GJB2 gene, which is responsible for intercellular substance transfer and signal communication, plays a critical role in hearin...

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Bibliographic Details
Main Authors: Penghui Chen, Wenjin Wu, Jifang Zhang, Junmin Chen, Yue Li, Lianhua Sun, Shule Hou, Jun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
connexin
cochlea
gap junction
hearing loss
mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.976388/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.976388/full

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