Highly Infectious Prions Generated by a Single Round of Microplate-Based Protein Misfolding Cyclic Amplification

Highly Infectious Prions Generated by a Single Round of Microplate-Based Protein Misfolding Cyclic Amplification

ABSTRACT Measurements of the presence of prions in biological tissues or fluids rely more and more on cell-free assays. Although protein misfolding cyclic amplification (PMCA) has emerged as a valuable, sensitive tool, it is currently hampered by its lack of robustness and rapidity for high-throughp...

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Main Authors: Mohammed Moudjou, Pierre Sibille, Guillaume Fichet, Fabienne Reine, Jérôme Chapuis, Laetitia Herzog, Emilie Jaumain, Florent Laferrière, Charles-Adrien Richard, Hubert Laude, Olivier Andréoletti, Human Rezaei, Vincent Béringue
Format: Article
Language:English
Published: American Society for Microbiology 2014-02-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00829-13

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https://journals.asm.org/doi/10.1128/mBio.00829-13

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